摘要
目的:分析降糖药致药品不良反应(ADR)的特点和规律,促进该类药物的合理应用。方法:收集我院2006年1月-2013年8月上报的降糖药致ADR报告359例,并对患者性别与年龄、药品种类、ADR累及器官或系统等情况进行统计和分析。结果:发生ADR的患者多为51岁以上的中老年人;涉及降糖药7类23种,其中磺酰脲类引发ADR最多,共90例,占25.07%;口服是ADR病例的主要给药途径;造成的损害累及10个器官或系统类型,胃肠道反应所占比例最大(占30.08%);给予相应处理后痊愈或好转的患者共341例,占94.99%;68.25%的ADR报告关联性评定为"很可能"。结论:降糖药引发的ADR较为常见,临床应用时应加强监护、及时处理,以确保用药的安全,提高治疗水平。
OBJECTIVE： To analyze the characteristics and regularity of ADR caused by antidiabetic drugs in order to promote rational use of antidiabetic drugs. METHODS： 359 ADR cases caused by antidiabetic drugs reported by our hospital were collected during Jan. 2006-- Aug. 2013, and analyzed statistically in respects of patient＇ s gender and age, drug varieties and ADR involved in organs or system. RESULTS： ADR mainly occurred in patients aged 51 years above; 7 varieties and 23 kinds of antidiabetic drugs were involved, most of which were caused by sulphonyluea （90 cases, 25.07% ）; most cases were induced by oral adminis- tration; 10 organs or systems were involved in ADR, and gastrointestinal reaction took the largest share （30.08%） ; 341 patients were improved or cured after given the appropriate treatment （94.99 % ）; 68.25 % of ADR reports were assessed as ＂very likely＂ in relevance. CONCLUSIONS： ADR induced by antidiabetic drugs are more common, intensive care and timely processing should be adopted to ensure the safety of medication and improve the level of treatment.
出处
《中国药房》
CAS
CSCD
2014年第10期920-922,共3页
China Pharmacy
