摘要
目的 测定异丙酚诱导时半数病人入睡的BIS值 (BIS50 )和半数有效剂量 (ED50 )。方法 选择 30例无服用精神和镇静催眠药物史、无术前用药的择期全麻手术成年病人 (ASAⅠ～Ⅱ级 ) ,以半数效量序贯方法进行异丙酚诱导的睡眠观察实验 ,以对指令反应和睫毛反射消失为入睡指标 ,同时记录BIS的变化 ,对取得的数据以直线回归的方法和加权均数法求得异丙酚的BIS50 和ED50 。结果 异丙酚的BIS50 和ED50 分别是 79 17(95 %可信范围 :72 0 8～ 88 5 5 )和 1 0 192mg/kg(95 %可信范围 :0 94～ 1 148mg/kg)。 结论 半数效量序贯实验方法简便、高效、结果可信 ,不仅适用于ED50 的测定而且同样适用于BIS50
Objective To determine the bispectral index and dose of propofol at which 50% of patients fall into unconsciousness during induction (BIS 50 and ED 50).Methods Thirty unpremedicated ASA Ⅰ-Ⅱ patients scheduled for elective surgery were included in this study.The patients did not take any sedatives or hypnotics and had no psychiatric disease.Loss of consciousness and changes in BIS during induction with propofol were studied by sequential experimental method.The loss of responses to verbal command and eyelash stimulation was used as an induction of unconsciousness.The data obtained were analyzed by linear regression and calculated to determine BIS 50 and ED 50 using weighted averaging method.Results The BIS 50 and ED 50 for propofol were 79.17 and 1.0192 mg/kg with the 95% confidence intervals of 72.08-88.55 and 0.94-1.148 mg/kg respectively.Conclusions The sequential experimental method for determination of ED 50 is simple, efficient and reliable and also suitable for determination of BIS 50.
出处
《中华麻醉学杂志》
CAS
CSCD
北大核心
2001年第1期7-9,共3页
Chinese Journal of Anesthesiology
