摘要
目的比较慢性阻塞性肺疾病急性加重期(AECOPD)及治疗后诱导痰细胞分类、血嗜酸粒细胞阳离子蛋白(ECP)的变化,探讨其在慢性阻塞性肺疾病(COPD)气道炎症中的作用。方法收集2011年6月至2012年8月住院的95例AECOPD患者,在入院当天和治疗7天后分别通过改良的诱导痰技术诱导痰标本进行细胞分类计数和抽血留取血标本通过荧光酶免疫法测定血ECP。结果在慢性阻塞性肺疾病急性加重期,中性粒细胞和嗜酸性粒细胞比例明显高于健康人群。经治疗后中性粒细胞比例下降、巨噬细胞比例上升(P=0.00<0.05),而嗜酸性粒细胞比例、血ECP略有下降,但差异无显著性(P>0.05)。结论中性粒细胞在慢性阻塞性肺疾病急性加重期明显升高,随病情缓解而降低,嗜酸性粒细胞和血ECP并不随病情缓解而降低。提示嗜酸性粒细胞主要参与慢性阻塞性肺疾病慢性炎症过程,可能与急性加重无明显相关;中性粒细胞除参与慢性阻塞性肺疾病慢性炎症外,还与急性加重期感染有关。
Objective To compare the induced sputum characters and serum ECP （ eosinophil cationic protein ） of COPD（chronic obstructive pulmonary disease） patients during acute exacerbation and the 7th day after treatment,and investigate its relationship with airway inflammation in COPD. Method 95 cases AECOPD （ acute exacerbation of COPD）patients between June 2011 to August 2012 in hospital were studied with induced sputum cell counts and serum ECP on the day of admission and the 7th day after treatment. Result The results showed that in the acute exacerbation of COPD,neutrophil and eosinophil proportion were significantly higher than those in healthy population. Neutrophil showed significant decline and macrophage percentage showed significant increase after treatment compared with before treatment（P=0. 00〈0. 05）,and the decline of eosinophil and serum ECP were not significant（P〉0. 05）. Conclusion Neutrophil was significantly higher in acute exacerbation of COPD, eosinophil and serum ECP were not reduced with remission. It prompted eosinophil was involved in chronic airway inflammation in chronic obstructive pulmonary dis-ease, while no significant correlation with acute exacerbation, neutrophil correlated with chronic airway inflammation and airway infection during acute exacerbation of chronic obstructive pulmonary disease.
出处
《中国临床医生杂志》
2014年第2期24-26,共3页
Chinese Journal For Clinicians
基金
广东省自然科学基金资助(9151170003000005)
