摘要
目的分析血清脂联素及胱抑素C在糖尿病肾病早期诊断中的价值。方法选取糖尿病患者组85例作为观察对象,并根据尿蛋白排泄率分为三组:正常蛋白尿组,微量蛋白尿组及临床蛋白尿组,同时选择健康体检者30例作为正常对照组。采用酶联免疫吸附试验(ELISA)检测血清脂联素水平,免疫比浊法检测血清胱抑素。结果糖尿病组血清脂联素及胱抑素水平明显低于正常对照组(P<0.05),而随尿蛋白排泄率的增加,血清脂联素及胱抑素水平逐渐增高(P<0.05),且血清脂联素与胱抑素呈正相关关系(r=0.652,P<0.05)。结论糖尿病患者血清APN水平的升高预示肾功能的减退,可用于糖尿病肾病的早期诊断。
Objective To evaluate the value of adiponectin and cystatin C on early diagnosis for renal impairment in diabetes. Methods A total of 85 diabetic patients were divided into normal albuminuria group, micro- albuminuria group and macro- albuminuria group according to urine albumin excretion rate in 24 hours. 30 health subjects were enrolled as controls. The serum levels of adiponectin and cys- tatin C were detected by ELISA kit. Results The serum levels of adiponectin and cystatin C in diabetic patients were obviously lower than that in the controls（P〈0.05）. For diabetic patients, the serum levels of adiponectin and cystatin C in macro- albuminuria group were significantly higher than in mi- cro- albuminuria group （P 〈 0. 05）. and they were also significantly higher in micro- albuminura group then that in normal albuminura group（P〈0.05）. The serum level of adiponectin in diabetic pa- tients was positively correlated with the serum levels of cystatin C（r = 0. 652,P〈0.05）. Conclusion In diabetic patients, the elevated serum levels of adiponectin indicates the decline of renal function. It can be used for the early diagnosis and estimation of diabetic nephropathy.
出处
《中国煤炭工业医学杂志》
2014年第2期248-250,共3页
Chinese Journal of Coal Industry Medicine
