摘要
目的 探讨青年人和老年人大肠癌的临床及病理特征。方法 对 14 7例青年人和老年人大肠癌患者的临床特征进行分析 ,测定患者血清CEA、CA2 4 2 ,采用免疫组化方法测定其 p5 3、c erbB2和CD44V 6蛋白的表达情况。 结果 青年组和老年组大肠癌在性别分布上无差异 ,2组中直肠癌均多于结肠癌 (P >0 .0 5 ) ,而青年组肿瘤细胞多数分化程度差 (低 未分化 ) ,老年组肿瘤细胞分化程度较好 (高 中分化 ) ;青年组病程较晚 (Duke′sC +D)病例的比例较老年组高 (P <0 .0 5 ) ;青年组和老年组CEA、CA2 4 2 、p5 3、c erbB2、CD 44V 6的阳性率分别为 34.1%、5 6 .1%、5 3 .7%、5 6 .1%、36 .6 %和 19.8%、2 3 .6 %、33 .0 %、37.7%、17.9% ,除CEA外 ,其余 4项指标 ,2组比较均有显著性差异 (P <0 .0 5 )。
Objective To study the clinical and pathological characters of young and old patients with colorectal cancer.Methods Clinical Characteristics of 41 young and 106 old patients with colorectal cancer were analyzed.Serum CEA and CA 242 levels were measured.p53 c erbB 2 and CD44V6 protein were detected by immunohistochemistry methods in all patients.Results There was no significant difference in sex and site of colorectal cancer between young and old patients.The rates of poor differentiated tumor cell and advanced stage(Duke′s C+D) in young patients were higher than those in old patients( P <0.05).The positive rate of CEA、CA 242 、p53、c erbB 2 、CD44V6 in young and old patients was 34.1%、56.1%、53.7%、56.1%、36.6% and 19.8%、23.5%、 33.0% 、37.7%、17.9% respectively.There were significant difference between young and old one in four items except CEA( P < 0.05 ).Conclusion There are different clinical charateristics and biological behavior between young and old patients with colorectal cancer.
出处
《实用癌症杂志》
2001年第1期70-71,83,共3页
The Practical Journal of Cancer
