摘要
目的:建立大川芎鼻用原位凝胶剂的质量标准。方法:采用TLC法对处方中天麻和川芎进行定性鉴别;并采用HPLC法测定天麻中天麻素,以及川芎中阿魏酸的含量。结果:薄层色谱检出天麻、川芎;天麻素在0.1132-1.698μg内呈良好的线性关系,r=0.9997;平均回收率为100.86%,RSD%=1.79%。阿魏酸在0.02705-0.2705μg内呈良好的线性关系,r=0.9992;平均回收率为98.94%,RSD%=1.42%。结论:该方法简便可行,重现性好,可控制该制剂的质量。
Objective： To establish a quality standard of the Rhizoma Chuanxiong nasal in situ gel agent. Methods： The TLC method was applied for the identification of Rhizoma Gastrodiae and Rhizoma Chuanxiong in the formula; the content of gastrodin in Rhizoma Gastrodiae and the content of ferulic acid in Rhizoma Chuanxiong were determined by HPLC. Results： Rhizoma Gastrodiac and Rhizoma Chuanxiong were found with TLC; Gastrodin showed good linear relationship at 0.1132-1.698 μg, within r=0.9997, and the average recovery was 100.86%; RSD% was 1.79%; Ferulic acid showed good linear relationship at 0.02705-0.2705μg, within r=0.9992; the average recovery was 98.94%, and RSD% was 1.42%. Conclusions： The method is simple and reproducible. It can be used to control the quality of the Rhizoma Chuanxiong nasal in situ gel agent.
出处
《中医药导报》
2014年第2期68-71,共4页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
基金
四川省科研院所科技成果转化资金项目(10010118)
