摘要
目的 探讨自身免疫病患者肾移植术后原发病复发的高危因素。方法 回顾分析 2 5例接受肾移植的自身免疫病患者的临床资料。结果 2 5例自身免疫病患者肾移植术后人 /肾 1、3、5年存活率与同期因其它原因所致的终末期肾功能衰竭而接受肾移植者相比 ,差异不显著 ;4例原发病复发者术前平均血液透析时间为 (2 3 .6± 17.5 )个月 ,2 1例未复发者的平均血液透析时间为 (2 5 .8±2 0 .1)个月 (P >0 .0 5 ) ;原发病复发者从发病至肾功能衰竭的时间较未复发者短 ,发病年龄明显高于未复发者。结论 自身免疫病患者可以接受肾移植术 。
Objective To investigate the outcome of renal transplantation in the patients with systemic autoimmune disease. Method The clinical data of 25 patients with autoimmune disease undergoing renal transplantation were retrospectively analyzed. Results The survival rate for 1 year, 3 years, 5 years after renal transplantation in the patients with autoimmune disease and without autoimmune disease were 88.0 ?%, 80.0 ?%, 72.0 ?% and 88.9 ?%, 84.4 ?%, 77.8 ?% respectively. The graft survival rate for 1 year,3 years, 5 years after renal transplantation in the patients with autoimmune disease and without autoimmune disease were 84.0 ?%, 72.0 ?%, 60.0 ?% and 86.2 ?%, 77.0 ?%, 66.4 ?% respectively. The average intervals of dialysis pre transplantation between the patients with recurrent underlying diseases (4 patients) and without recurrent underlying diseases (21 patients) was not difference. Among the 4 patients with positive ANA and elevated anti dsDNA serology pre and post transplant, 2 patients had recurrent underlying diseases. Conclusions Renal transplantation should be offered to the patients with autoimmune diseases because relapses of underlying diseases after renal transplantation seem to be rare. The patient and graft survival rate was not significantly different in the patients with autoimmune diseases and without autoimmune diseases.
出处
《中华器官移植杂志》
CAS
CSCD
北大核心
2001年第1期11-13,共3页
Chinese Journal of Organ Transplantation
