摘要
目的 系统评价养血清脑颗粒治疗高血压伴随症状的疗效.方法 采用计算机检索中国知网、万方数据库自建库以来至2013年5月公开发表的与养血清脑颗粒治疗高血压伴随症状相关的随机对照试验（randomized controlled trials,RCTs）,并手工检索相关期刊,对筛选出的文献查找全文,经质量评价最终纳入文献后采用Review Manager 5.0软件进行Meta分析.结果共纳入10篇文章,共计1 777例患者.Meta分析结果显示：在治疗终点,养血清脑颗粒组高血压伴随头痛、头晕、失眠的疗效优于对照组,有效率的危险比（risk ratio,RR）及其95%可信区间（confidence interval,CI）分别为（RR=1.37;95% CI：1.27～1.47;P〈0.01）、（RR=1.34;95% CI：1.21～1.48;P〈0.01）、（RR=2.20;95% CI：1.36～3.54;P〈0.01）.结论养血清脑颗粒能显著改善高血压性头痛、头晕、失眠症状,但尚需更多大样本、高质量RCTs进一步验证.
Objective To systematically evaluate the efficacy of Yangxue Qingnao Granule in the treatment of the associated symptoms of hypertension. Methods A computer search was performed using CNKI and Wanfang Data to identify the randomized controlled trials （RCTs） of Yangxue Qingnao Granule for treating the associated symptoms of hypertension published up to May 2013, and relevant journals were manually searched; the identified studies were finally selected after full-text search and quality assessment and then subjected to metaanalysis using Review Manager 5.0. Results A total of 10 RCTs involving 1 777 patients were included in the meta-analysis. The meta-analysis showed that at the end of treatment, the Yangxue Qingnao Granule group had a significantly higher risk ratio （RR） of efficacy than the control group in terms of headache （RR=1. 37; 95% CI： 1.27 - 1.47; P〈0.01）, dizziness （RR=I. 34; 95% CI： 1.21 -1.48; P〈0.01）, and insomnia （RR=2.20; 95% CI= 1.36-3.54; P〈0.01）. Conclusion Yangxue Qingnao Granule can significantly relieve headache, dizziness, and insomnia in hypertensive patients, but which needs to be further confirmed by more large-sample, high-quality RCTs1.
出处
《安徽中医药大学学报》
CAS
2014年第1期8-11,共4页
Journal of Anhui University of Chinese Medicine
关键词
养血清脑颗粒
高血压伴随症状
疗效
META分析
Yangxue Qingnao Granule
associated symptoms of hypertensionl
effieaey
Meta-analysis
