摘要
目的通过Meta分析评估醛固酮合成酶CYP11B2(-344C/T)基因多态性与原发性高血压左室肥厚之间的相关性。方法查阅1980年1月-2012年12月发表的有关CYP11B2基因多态性与中国汉族人群原发性高血压左室肥厚关系的病例对照研究文献,选择的数据库有中国期刊全文数据库、中国生物医学文献数据库、维普中文期刊数据、万方数据库及Pubmed。以左室肥厚组[LVH(+)]和无左室肥厚组[LVH(-)]基因分布的OR值为统计量,应用RevMan 5.1软件对各研究结果进行异质性检验和数据合并。结果最终入选6篇病例对照研究文献。共入选原发性高血压患者1 791例。LVH(+)组与LVH(-)组CC/(TT+TC)OR=1.21,95%CI(0.80,1.81),P=0.36;(TC+CC)/TT OR=1.16,95%CI(0.68,1.98),P=0.59;LVH(+)组与LVH(-)组C等位基因/T等位基因频率OR=1.09,95%CI(0.78,1.54),P=0.61。结论中国人的CYP11B2基因多态性与原发性高血压左室肥厚无关。
Objective To investigate the association between CYP11B2 gene polymorphism and left ventricular hypertrophy in Chinese hypertensive patients by the means of meta-analysis. Methods Literatures about case control study on the association of CYP11B2 gene polymorphism and left ventricular hypertrophy were searched from January 1980 to December 2012. The electronic databases searched included China national knowledge internet, Chinese biological medicine disk, Vip fulltext database, Wanfang fulltext database and Pubmed. Odds ratio （OR） of CYP11B2 genotype distributions in left ventricular hypertrophy （LVH） patients against NLVH patients were analyzed. RevMan 5.1 software was applied for investigating heterogeneity among individual studies and summarizing effects across studies by proper statistical methods. Results Six case-control studies were selected finally. A total of 1 791 hypertensive patients were included. The pooled OR （95% CI） of CC vs. TT＋TC genotype was 1.21 （0.80, 1.81） （Z=0.91, P=0.36）, the pooled OR （95% CI） of （TC＋CC） vs. TT genotype was 1.16 （0.68, 1.98） （Z=0.54, P=-0.59）, and the pooled OR （95% CI） of C vs. Y allele was 1.09 （0.78, 1.54） （Z=0.51, P=0.61）. Conclusion The genotype of CYP11B2 polymorphism is not associated with an increase risk of left ventricular hypertrophy in Chinese hypertensive patients.
出处
《华西医学》
CAS
2014年第2期239-242,共4页
West China Medical Journal
基金
滨州医学院科研启动基金(BY2010KYQD05)~~
关键词
高血压
左室肥厚
醛固酮合成酶
基因多态性
META分析
Hypertension
Left ventricular hypertrophy
Aldosterone synthase
Gene polymorphism
Meta-analysis
