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组蛋白乙酰化与糖尿病 被引量：6

Role of histone acetylation in diabetes mellitus
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摘要 组蛋白乙酰化是表观遗传学组蛋白修饰的重要内容，组蛋白乙酰化参与糖尿病及其并发症的发生，其机制包括介导高血糖的“代谢记忆”效应、干扰胰岛的发育和调节炎症因子及致病基因的表达等。全基因组关联研究方法正在逐渐揭示糖尿病的发病机制。并且越来越多的研究表明组蛋白去乙酰化酶可以作为糖尿病治疗的新靶点。 Histone acetylation is a crucial part of histone modifications in epigenetics. Histone acetylation is involved in the onset of diabetes and diabetic complications, through the mechanism of inducing hyperglycemia by means of＂ metabolic memory＂ effect, interfering islet development and regulating the expression of inflammatory factors and pathogenic genes. Genome-wide association studies are gradually unveilling the pathogenesis of diabetes and preclinical studies are rapidly elucidating that histone deacetylase should be considered as a new target for the treatment of diabetes.
作者 王燕飞 侯粲 苏欣 周智广
机构地区 中南大学湘雅二医院内分泌科
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2014年第2期167-170,共4页 Chinese Journal of Endocrinology and Metabolism
基金 国家自然科学基金青年基金（81200580） 中央高校青年教师助推专项资助（2012QNZTl57） 教育部博士点基金新教师类（20120162120090）
关键词 糖尿病 组蛋白乙酰化 代谢记忆 全基因组关联研究 Diabetes mellitus Histone acetylation Metabolic memory Genome wide association studies
分类号 R587.1 [医药卫生—内分泌]
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参考文献35

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二级参考文献55

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共引文献7

同被引文献66

  • 1赵晓云,邢邯英,裴华颖,高宇.内源性一氧化碳在糖尿病大鼠股动脉舒张反应障碍中的作用[J].北京大学学报（医学版）,2005,37(4):389-392. 被引量：4
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引证文献6

二级引证文献9

中华内分泌代谢杂志
2014年 第2期

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