摘要
目的:不同致敏原诱发豚鼠过敏性鼻炎模型的比较。方法:分别以卵蛋白(OVA)、2,4-二异氰酸甲苯酯(TDI)和互隔交链孢霉作为致敏原诱发豚鼠制备过敏性鼻炎模型,以行为学观察、血清生化水平和组织学观察,考察不同模型组与人类过敏性鼻炎的符合度。结果:OVA组与空白组比较,打喷嚏次数、抓鼻次数、血清透明质酸(HA)及IgE差异有统计学意义(P<0.001或0.01)。结论:OVA诱发过敏性鼻炎模型既在症状上符合过敏性鼻炎的典型症状,又在病理改变上与过敏性鼻炎相符合。
Objective： To compare the models of guinea pig allergic yhinitis induced by different allergens. Methods： Ovalbumin （OVA）, 2,4-tolylene diisocyanate （TDI） and ahernariaalternata was respectively used as the allergens to establish the model of guinea pigs allergic rhinitis. The conformity of the models and human allergic rhinitis was studied through the behavioral indices, such as the times of nose itches, nasal discharge flow, histological properties and serum HA and IgE indices. Results： The times of sneezing and scratching nose, serum HA and lgE in OVA group was significantly different from those in the control group （ P 〈 0.001 or P 〈 0.01 ）. Conclusion： The models of allergic rhinitis induced by OVA are the same as allergic rhinitis in typical symptoms and pathological changes.
出处
《中国药师》
CAS
2014年第2期196-198,共3页
China Pharmacist
基金
黑龙江省自然科学基金项目(编号:D201038)
关键词
过敏性鼻炎
模型
致敏原
Allergic rhinitis
Models
Allergen
