摘要
目的了解2012年深圳市光明新区人民医院临床分离菌对常用抗菌药物的耐药性。方法采用Microscan auto 4鉴定及药敏系统对临床常规细菌进行监测,按CLSI2009年版标准判断药敏结果 ,并用WHONET 5.4软件统计分析。结果全年共分离细菌1 818株,其中革兰阳性菌占35.6%,革兰阴性菌占58.0%。葡萄球菌中耐甲氧西林金黄色葡萄球菌(MRSA)占18.3%,凝固酶阴性葡萄球菌(MRCNS)占71.9%。肺炎链球菌中青霉素非敏感的肺炎链球菌(PNSSP)占20.7%。大肠埃希菌和肺炎克雷伯杆菌产ESBLs菌株分别占43.2%和22.4%。检出5株亚胺培南耐药的肠杆科细菌。铜绿假单胞菌和鲍曼不动杆菌对头孢他啶、哌拉西林、妥布霉素、阿米卡星、环丙沙星、亚胺培南的耐药率均低于10%。结论本院常见致病菌耐药性不是十分严重,尤其是院内感染的铜绿假单胞菌和鲍曼不动杆菌对常用抗菌药物耐药率较低。
Objective To investigate the antibiotic resistance of clinical isolates collected from the t＇eople＇s Hospital oI Guangming New District in 2012. Method Identification of isolates and antimicrobial susceptibility test were carried out by Microscan auto 4 system, and WHONET 5.4 software was employed for data analysis according to CISI2009 standards. Results 1 818 non-duplicate isolates were collected.Gram positive bacteria and gram negative bacteria accounted for 35.6% and 58.0% ,respectively. 18.3% Staphylococcus aureus and 71.9% oagulase negative Staphylococcus were resistant to oxacillin; 20.7% S.pneumoniae were not susceptible to penicillin; 43.2% E.coli and 22.4% K.pneumoniae isolates produced ESBLs. 5 imipenem-resistant strains of Enterobacteriaceae were found. The resistance rates of P. aeruginosa and A. baumannii to ceftazidime, piperacillin, tobramycin, amikacin, ciprofloxacin and imipenem were lower 10%. Conclusion Common hospital pathogen drug resistance is not very serious, especially nosocomial infection Pseudomonas aeruginosa and Acinetobacter baumannii showed low resistance to commonly used antimicrobial drugs.
出处
《热带医学杂志》
CAS
2014年第1期91-93,共3页
Journal of Tropical Medicine
关键词
细菌耐药性
抗菌药物
药敏试验
bacterial resistance
antimicrobial agent
susceptibility test
