摘要
目的:观察苍附导痰汤加减与达英-35及氯米芬联合治疗多囊卵巢综合征(PCOS)不孕的临床疗效及安全性。方法:将PCOS不孕患者48例随机分2组各24例,均在月经周期第5天给予达英-35口服3个月经周期,第4个月经周期第5天起口服枸橼酸氯米芬片。治疗组在对照组基础上于月经周期第5天加用苍附导痰汤治疗6个月经周期。观察2组月经恢复情况、注射HCG日激素水平、子宫内膜厚度及成熟卵泡数、排卵率、妊娠率及不良反应。结果:总有效率治疗组为83.3%,对照组为54.2%,2组比较,差异有显著性意义(P<0.05)。经治疗后,治疗组HCG注射日雌二醇及黄体生成素水平、子宫内膜厚度、优势卵泡数、促卵泡天数均优于对照组(P<0.05)。2组排卵率及妊娠率比较,差异均有显著性意义(P<0.05)。结论:苍附导痰汤加减与达英-35及氯米芬联合治疗PCOS不孕,疗效确切,值得临床推广。
Objective： To explore the clinical efficacy and safety of the combination use of Cang Fu Daotan Decoction, Diane-35 and clomiphene on infertility induced by polycystic ovary syndrome（PCOS）. Methods： Forty-eight PCOS infertility patients were equally randomized into 2 groups. Air of the patients were given oral use of Diane-35 on day 5 of menstrual cycle and the treatment lasted 3 menstrual cycles, and the medication was changed into oral use of clomiphene citrate tablets on menstrual cycre 4. Additionally, the treatment group was given Cang Fu Daotan Decoction on day 5 of menstrual cycle and the treatment lasted 6 menstrual cycles. After treatment, we observed the menstruation recovery, hormone levels on HCG injection day, endometrial thickness and the number of mature follicles, ovulation rate, pregnancy rate and adverse reactions. Results： The total effective rate in the treatment group was 83.3% and was 54.2% in the control group, and the difference was statistically significant between the two groups （P 〈 0.05）. After treatment, estradiol and luteinizing hormone levels on HCG injection day, endometrial thickness, number of dominant follicles, and days for promoting follicles were improved in the treatment group as compared with those in the control group（P 〈 0.05）. the differences of ovulation rate and pregnancy rate between the two groups were statistically significant（P 〈 0.05）. Conclusion. The combination use of Cang Fu Daotan Decoction, Diane-35 and clomiphene is effective and safe for the treatment of PCOS infertility.
出处
《新中医》
CAS
2014年第3期104-106,共3页
New Chinese Medicine
