摘要
多囊卵巢综合征(PCOS)是女性生殖内分泌疾病,同时存在代谢障碍。作者从PCOS是原发卵巢的疾病,卵泡功能异常是PCOS病变的核心、胰岛素抵抗是PCOS的关键病理机制和胰岛素增敏剂的有效治疗生殖障碍等方面,论证PCOS可能是原发性卵泡病,甚至可能是胰岛素抵抗卵泡病的学术观点,为PCOS的基础研究提供可能的研究思路。
Polycystic ovary syndrome is characterized by reproductive endocrinology and metabolic abnormalities. This paper reviewed recent advance in science frontier about PCOS including： ① PCOS manifests as primary ovary disorder; ②The core features in PCOS are associated with increased size and functionalities of follicles, ③Insulin resistance constitutes the key pathophysiology of PCOS; ④ Insulin sensitizing agents are effective in treating the reproductive and metabolic disorders. Thus, it is hypotheses that PCOS may be a primary disorder of follicles and perhaps a follicular disorder of insulin resistance. Such an idea offers new direction for future research for PCOS.
出处
《医学研究生学报》
CAS
2006年第11期1040-1043,共4页
Journal of Medical Postgraduates
关键词
多囊卵巢综合征
胰岛素抵抗
卵泡病
Polycystic ovary syndrome
Insulin resistance
Follicular disorder
