摘要
目的:比较坦度螺酮、文拉法辛和劳拉西泮对广泛性焦虑症的疗效、安全性及治疗依从性的差异。方法:将108例广泛性焦虑症患者随机分入坦度螺酮组(36例)、文拉法辛组(36例)和劳拉西泮组(36例),分别给予相应的药物治疗6周,半年后随访。治疗前、治疗后1、2、6周末和半年后随访时应用汉密尔顿焦虑量表(HAMA)和副反应量表(TESS)评定疗效和副反应。结果:文拉法辛组和劳拉西泮组患者治疗第1周末HAMA总分较治疗前有显著下降(P<0.01),坦度螺酮组患者治疗第2周末HAMA总分较治疗前有显著下降(P<0.01)。半年后随访时劳拉西泮组患者HAMA总分显著高于坦度螺酮组和文拉法辛组(P<0.05)。坦度螺酮组、文拉法辛组和劳拉西泮组的显效率分别为69.4%、72.2%、69.4%、经x2检验差异无显著性(P>0.05)。坦度螺酮组和文拉法辛组副反应的总发生率均显著低于劳拉西泮组(P<0.05)。半年后随访时坦度螺酮组和文拉法辛组服药依从性好者显著高于劳拉西泮组(P<0.05)。结论:坦度螺酮和文拉法辛治疗广泛性焦虑症的短期疗效与劳拉西泮无明显差别,中期疗效和服药依从性明显优于劳拉西泮,副反应的发生率低。
Objective：To compare Tandospirone , Venlafaxine and Lorazepam on efficacy and safety of generalized anxiety and medica -tion adherence.Methods：108 patients with generalized anxiety were randomly assigned to Tandospirone treatment group （36 cases）,Ven-lafaxine treatment group（36 cases） and Lorazepam treatment group （36 cases） . All the patients were respectively gave corresponding drug treatment for 6 weeks ,and follewed up after six months .The hamilton Depression Anxiety Scale （ hAMA） and Treatment Emergent＆amp;nbsp;Symptoms Scale（TESS） were used to assess the efficacy and side effects .Results：The hAMD scores significantly declined after 1 week end treatment in Venlafaxine group and lorazepam group patients （P〈0.01）,and the Tandospirone group patients showed significantly de-clined of the hAMA scores after 2 week end （P〈0.01）.The hAMD scores were significantly higher than Venlafaxine group and Loraze-pam group after six months follow -up （P〈0.05）.The significant improvement rates of Tandospirone group ,Venlafaxine group and loraz-epam group show 69.4%, 72.2%and 69.4%respectively, there was no significant difference by X2 Test（P〉0.05）.The incidence of side effects of Tandospirone group and Venlafaxine group were significantly lower than that of lorazepam group （P〈0.05）.After six months follow-up, the medication adherence of Tandospirone group and Venlafaxine group were significantly higher than that of Loraze -pam group（P〈0.05）.Conclusion：There was no evident difference on short -term efficacy in the treatment on generalized anxiety of with Lorazepam .But Tandospirone and Venlafaxine had evident better dcurative effect and medication adherence than Lorazepam .and lower in-cidence of adverse events .
出处
《中国伤残医学》
2014年第4期35-37,共3页
Chinese Journal of Trauma and Disability Medicine
