摘要
砷是地球上广泛分布的一种有毒类金属元素,氧化胁迫是其主要毒性.目前,砷也被证明具有内分泌干扰作用.本文简要综述了环境砷的人群暴露和代谢情况,总结了砷影响男性精子质量和不育症的流行病学证据,结合动物模型的研究结论,探讨了砷通过氧化胁迫途径干扰激素合成和代谢,进一步引发雄(男)性生殖毒性的机制.
Arsenic is a widely distributed element in the earth, and oxidative stress is its main toxicity. Now, arsenic has been proved to have endocrine disruption function. We briefly reviewed the human exposure routes to arsenic andits metabolism, and summarized the epidemiology evidence of the arsenic effects on male semen quality and infertility. In further, based on the in vitro and in vivo results, we discussed the mechanisms of arsenic disturbed the synthesis and metabolism of hormone through oxidative stress and damaged male reproduction function, and finally resulted in male infertility.
出处
《科学通报》
EI
CAS
CSCD
北大核心
2014年第3期238-244,共7页
Chinese Science Bulletin
基金
国家自然科学基金(21177123)
中国科学院"百人计划"项目
厦门市科技项目(3502Z20122003)资助
关键词
砧
氧化胁迫
精液质量
男性不育
Arsenic, oxidative stress, semen quality, male infertility
