摘要
目的了解新辅助化疗(NACT)对宫颈癌的近期疗效,分析NACT前后Nanog,Twist表达变化并研究其临床意义。方法应用免疫组化染色的方法检测正常宫颈、CIN、宫颈癌活检及NACT后宫颈癌标本中Nanog与Twist的表达。结果 Nanog,Twist在正常宫颈、CIN及宫颈癌中表达阳性率依次升高,分别为10%,65%,84%和13.3%,45%,66%.Nanog,Twist在NACT后宫颈癌有效组及无效组的表达阳性率分别为30%和70%,20%和80%.结论Nanog,Twist在宫颈癌发生、发展中起重要作用,且可能参与宫颈癌多药耐药形成。
Objective To observed the effect of neoadjuvant chemotherapy （ NACT） on cervical cancer and to,analysis the differences of NACT Nanog ,Twist expression between before and after the NACT .Methods Immunohis-tochemical staining was used to detect the expression of Nanog and Twist among normal cervix ,CIN,cervical biopsy and cervical cancer specimens after NACT.Results From the normol cervix to Cervical Cancer ,The expression of Nanog, Twist were increased：10%,65%,84%,13 .3%,45%,66%.The positive expression of Nanog ,Twist in two groups were 30%and 70%,20%and 80% respectively.Conclusion Nanog,Twist plays an important role during cervical cancer occurrence and development ,and may be involved in the formation of cancer multidrug resistance .
出处
《潍坊医学院学报》
2013年第6期465-467,共3页
Acta Academiae Medicinae Weifang
