摘要
目的观察补肾填精活血方治疗血管性痴呆(VD)的临床疗效及其对血浆同型半胱氨酸(Hcy)、β-淀粉样蛋白(Aβ)的影响。方法将符合标准的80例VD患者按随机分配原则分为治疗组和对照组,各40例。在常规治疗基础上,治疗组加用补肾填精活血汤治疗,对照组加用尼莫地平治疗,比较两组治疗后中医证候积分、血浆Hcy和Aβ水平变化。结果治疗后两组中医证候积分分别为14.25分±2.13分与16.01分±2.46分,均较治疗前有下降(P<0.01),且治疗组中医证候积分较对照组更低(P<0.01)。治疗后治疗组Hcy、Aβ水平较对照组降低(P<0.01)。结论补肾填精活血方对VD患者中医证候评分改善明显,且不良反应少,可能与其能使患者Hcy、Aβ下降有关。
Abstract：Objective To observe the clinical effect of Bushen Tianjing Huoxue prescription （BTHP） on vascular dementia（VD）, and study its e{feet on homocysteine （Hcy） and amyloid - β（Aβ）. Methods Eighty patients with VD were randomly divided into two groups ： Control group（n= 40） treated with routine treatment and nimodipine, and treatment group（n = 40） treated with routine treatment and BTHP. The changes of traditional Chinese medicine（TCM） syndrome scores, the levels of Hcy and Aβ after treatment in two groups were compared. Results After treatment,TCM syndrome scores in two groups were decreased （P〈0.01） ,and the TCM syndrome scores in treatment group were lower than those in control group（P〈0.01）. After treatment, the levels of Hcy and Aβ in treatment group were lower than those in control group（P〈0.01）. Conclusion BTHP can improve the TCM syndrome,which may be relate to decreasing of the level of Hcy and Aβ.
出处
《中西医结合心脑血管病杂志》
2014年第1期16-18,共3页
Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
关键词
血管性痴呆
中医证候积分
补肾填精活血方
同型半胱氨酸
Β-淀粉样蛋白
vascular dementia
traditional Chinese medicine syndrome score
Bushen Tianjing H uoxue prescription
homocysteine
amyloid - β
