摘要
目的 探讨卡托普利对平滑肌细胞增生、移行、动脉硬化形成和发展的影响 ,并进一步研究动脉粥样硬化 (AS)的发病机制和 AS家兔模型的制作方法。方法 选择日本大耳白兔利用高脂、高胆固醇膳食法建立 AS模型 ,制作过程中动态观察血胆固醇 (TC)、甘油三酯 (TG)、低密度脂蛋白 (LDL)、高密度脂蛋白 (HDL)水平。实验结束后处死动物做病理学检查 (光镜和电子显微镜 ) ,并做 AS面积的测定。结果 卡托普利和硒维尔 +VE联合用药可抑制 TG及 LDL的升高 ,而对 HDL和 TC影响不大。 AS斑块面积的测定以预防组最小。病理电镜片可见动脉硬化组内皮细胞坏死、脂质沉积 ,SMC以合成表型为主 ,硒维尔 +VE联合用药内皮改变轻 ,卡托普利预防组内膜良好无明显泡沫细胞 ,SMC以收缩型为主。结论 卡托普利对 AS发生、发展的重要因素 LDL、平滑肌细胞移和增生。
Objective To study the effects of captopril in atherosclerosis.Methods The models were developed by feeding high triglyceride,high cholesterol diet.Serial measurement of blood cholesterol,triglycerides,HDL,LDL of the rabbits were performed through out this period.At the end of the experiment,the rabbits were killed and pathologic examinations were performed and the atherosclerosis lesion areas were measured.Results Increase of TG and LDL levels of the rabbits were inhibitted in captopril pretreatment group and selenium+Vitamine E treatment group,but there were no significant differences in HDL and cholesterol levels in these groups.The area of atherosclerosis lesions of the rabbits was the smallest in pretreatment group compared with the other groups( P <0 01).Electron microscopic pathologic examination showed that in atherosclerosis group,there were endothelium necrosis,lipid deposits and SMC were mainly synthesized type,whereas in selenium+Vitamine E treated group the changes of endotheium were insignifcant and SMC were mainly contracted type.Conclusions The study show captopril can delay the progress of the formation and development of athersoclerosis from various pathways.
出处
《中国老年学杂志》
CAS
CSCD
北大核心
2001年第1期52-55,共4页
Chinese Journal of Gerontology
