摘要
本实验对雄性新西兰白兔的实验性动脉粥样硬化进行超微结构及组织化学研究。结果证明,血源性单核细胞为早期斑块内泡沫细胞的主要来源;单核巨噬细胞源性泡沫细胞可返回血流,起清除病灶内脂质的作用。非特异性酯酶及酸性磷酸酶染色是判断泡沫细胞来源的可靠方法。
30 male New Zealand albina rabbits were used for ultrastructural and histochemical investigation on experimental atherosclerosis.The results demonstrated that blood-borne monocytes are the major sources of foam cells of early atherosclerotic lesions.A significant phenomenon was noticed,that is,after 8 weeks on the diet,there was a considerable amount of macrophage-derived foam cells adhering to the endothelial cells or free in the blood stream.Electron microscopic examination showed that these foam cells were often trapped between the two endothelial cells.This implies that blood-borne macrophage-derived foam cells can return to the blood stream.The role played by these foam cells in atherogenesis was discussed.Nonspecific esterase and acidic phosphatase staining proved to be a reliable method in the identification of the origin of foam cells.
出处
《同济医科大学学报》
CAS
CSCD
北大核心
1990年第2期89-91,共3页
Acta Universitatis Medicinae Tongji
基金
国家自然科学基金委员会资助
关键词
动脉粥样硬化
单核巨噬细胞
病理
monocyte/macrophage
histochemical investigation, atherosclerosis
