摘要
目的分析替加环素治疗血液病粒细胞缺乏患者疑诊耐药菌感染中的疗效和安全性。方法收集2012年5月一2013年4月医院血液科收治的44例伴粒细胞缺乏疑诊耐药菌感染的血液病患者，予替加环素100mg负荷剂量，继以50mg12h一次维持剂量抗感染治疗，按用药情况分为单用替加环素组21例、初始单用替加环素后联合其他抗菌药物组9例及初始即联合其他抗菌药物组14例，按卫生部2007年颁布的抗菌药物疗效标准评价其疗效，同时观察其不良反应。结果44例粒细胞缺乏血液病患者共治愈19例，治愈率为43．2％，治疗有效患者，体温恢复正常平均时间2．47d；单用替加环素、初始单用替加环素后联合其他抗菌药物、初始即联合其他抗菌药物的患者治愈率分别为47．6％、44．4％、35．7％；替加环素的不良反应发生率为25．0％，主要为恶心、呕吐、腹泻，分别占15．9％、13．6％、6．8％。结论替加环素治疗粒细胞缺乏血液病患者耐药菌感染具有较好的疗效；对于碳青霉烯类等广谱抗菌药物治疗3～5d无效，考虑耐药菌感染的患者，可尽早应用替加环素治疗，替加环素引发的不良反应较少。
OBJECTIVE To analyze the curative effect and the safety of Tigecycline in treatment of agranulocytosis patients suspected of resistant bacteria infection. METHODS A total of 44 agranulocytosis patients suspected of resistant bacteria infection hospitalized from May 2012 to Apr. 2013 in hematology department were collected and treated with Tigecycline （100mg loading dose, followed by a maintenance dose of 50rag ql2h）. A!.I patients were divided into three groups： Tigecycline alone （21 cases）, single-use initially then combination with other antibiotics （9 cases）, initial combination with other antibiotics （14 cases）. The curative effect was evaluated, according to the Ministry of Health issued in 2007, meanwhile the drug side effect were observed. RESULTS Among all the 44 cases of agranulocytosis patients with infection, 19 cases were cured, with cure rate 43. 2~. Among all the patients with effective treatment, the average time of body temperature returnong to normal was 2.47d; The cure rates of three groups were 47. 6~, 44. 4%, 35. 7~, respectively. The adverse effect incidence rate of using Tigeeycline was 25. 0M, mainly including nausea, vomiting and diarrhea, accounting for 15.9%, 13. 6~ and 6.8~, respectively. CONCLUSION Tigecycline is effective in treating agranulocytosis patients with resistant bacteria infection. When the patients with resistant infection bacteria were treated with earbopenems antibiotic and other broad-spectrum antibiotics for 3-5 days without efficacy, Tigecycline can be considered to be used as soon as possible. The side effects of Tigeeyeline is few.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2014年第4期860-862,共3页
Chinese Journal of Nosocomiology
基金
江苏省临床医学中心基金资助项目(ZX201102)
国家高科技研究发展计划(863计划)基金项目(2012AA02A505)
江苏高校优势学科建设工程基金资助项目(PAPD)
