摘要
目的观察地黄益智方治疗肾精亏虚兼痰瘀阻络非痴呆型血管性认知功能障碍的临床疗效。方法将72例患者随机分为治疗组和对照组,每组36例。两组均予针对血管危险因素的基础治疗措施,治疗组同时加用地黄益智方,对照组加用盐酸多奈哌齐。两组疗程均为4个月,观察简易智能精神状态检查量表(MMSE)、蒙特利尔认知评估量表(MOCA)、日常生活活动量表(ADL)及中医症状积分变化情况。结果治疗前后组内比较,治疗组MMSE、MOCA、ADL及中医症状积分差异均有统计学意义(P<0.05),对照组MMSE、MOCA、ADL积分差异有统计学意义(P<0.05)。组间治疗后比较,ADL及中医症状积分差异有统计学意义(P<0.05)。结论地黄益智方可有效改善肾精亏虚兼痰瘀阻络非痴呆型血管性认知功能障碍患者的认知功能、反应能力及临床症状。
Objective To observe the clinical efficacy of ＂ Dihuang Yizhi Formula＂ for the treatment of vascular cognitive impairment no dementia （VCIND）. Methods Seventy-two cases were randomized into treatment group and control group, with 36 cases in each group. Both of the groups were treated with basic therapeutic measures. Additionally, treatment group was treated with ＂Dihuang Yizhi Formula＂, and control group were treated with donepezil, with the course of 4 months. The changes of MMSE, MOCA, ADL and TCM symptom scores were evaluated. Results In treatment group, there were significant differences in the scores of MMSE, MOCA, ADL and TCM symptom between before and afier treatment （P 〈 0.05 ） ; in control group, there were significant differences in the scores of MMSE, MOCA and ADL in control group （P 〈 0.05 ）. After treatment, significant differences were found in scores of ADL and TCM symptom between the two groups （P 〈 0.05 ）. Conclusion ＂ Dihuang Yizhi Formula＂ can improve the cognitive function, response capability and clinical symptoms in patients with VCIND of kidney-essence deficiency and phlegm stagnation types.
出处
《上海中医药杂志》
2014年第2期37-39,共3页
Shanghai Journal of Traditional Chinese Medicine
基金
上海市教委预算内项目(2012JW34)
上海市科委中药现代化项目(12401904400)
全国名老中医专家传承工作室建设项目
上海市中医药发展三年行动计划项目(ZYSNXD-CC-HPGC-JD-003)
关键词
非痴呆型血管性认知功能障碍
肾精亏虚
痰瘀阻络
地黄益智方
vaseular eognitive impairment no dementia （VCIND）
kidney-essence deficiency
phlegm stagnation
＂Dihuang Yizhi Formula＂
