摘要
目的:研究轻度认知障碍(MCI)的症状特点及中医辨证分型,揭示 MCI 的中医辨证分型与自由基代谢和胆碱酯酶的关系。方法:参考目前国际公认的 MCI 诊断标准,筛选出44名 MCI 患者,另选20名健康者为对照,进行相关神经心理学量表的测试,结合中医辨证确定证型。检测血清中乙酰胆碱酯酶(AchE)、超氧化物歧化酶(SOD)活性,血清丙二醛(MDA)含量及白细胞线粒体 DNA 缺失率。结果:MCI 患者中虚证27例(61.4%),虚实夹杂证17例(38.6%),93.18%的 MCI 患者均有肾虚髓空的症状。MCI 的虚证、虚实夹杂证组血清中 MDA、AchE 的含量及白细胞线粒体 DNA 缺失率较健康对照组明显增高,SOD含量、记忆商较健康对照组明显降低。除白细胞线粒体 DNA 缺失率外,虚实夹杂证组记忆商、血清中 MDA、AchE 含量又较虚证组明显增高,SOD 含量较虚证组明显降低。结论:MCI 患者中医证型有其客观的物质基础,即存在不同程度记忆损伤、自由基代谢和胆碱酯酶代谢的紊乱。
Objective:To study on symptom characteristics and TCM syndrome types of mild congnitive impairment(MCI),and reveal the relation of TCM syndrome types of MCI with metabolism of free radicals and cholin esterase.Methods:With reference to internationally acknowledged criteria for MCI diagnosis at present,44 cases of MCI were selected and 20 healthy persons were used as controls.Relative neuropsychological scales tests were conducted and TCM syndrome types were established.Serum acetycholin esterase(AchE),superoxide dismulase(SOD)activities,serum malondialdehyde(MDA)content and DNA defect rate in mitochondria of white cells were determined.Results:27 cases(61.4%)of deficiency syndrome,17 cases(38.6%)of coexistence of deficiency and excess syndromes and 93.18% patients of MCI had the symptoms of kidney-deficiency and hollow marrow.Serum MDA level and AchE activity and the DNA defect rate of mitochondria in white blood cells in the patients of deficiency syndrome and coexistence of deficiency syndrome and excess syndrome increased significantly and SOD activity and memory quotient significantly decreased as compared with the healthy persons.Memory quotient,serum MDA level and AchE activity in the patients of coexistence of excess and deficiency syndromes increased significantly and SOD activity decreased significantly as compared with the patients of deficiency syndrome.Conclusion:TCM syndrome types of the patient of MCI have objective substance basis,i,e.varying degrees of memory impairment and disturbances of metabolism of free radicals and AchE.
出处
《中医杂志》
CSCD
北大核心
2005年第4期291-293,共3页
Journal of Traditional Chinese Medicine
基金
北京大学"985"资助项目
首都医学发展科研基金重点资助项目(03-Ⅱ-04)
