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戊型肝炎病毒兔分离株相关研究进展 被引量:1

Research progress on hepatitis E virus rabbit strains
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摘要 戊型肝炎病毒(hepatitis E virus,HEV)是引起急性病毒性肝炎的病原体之一。HEV主要经粪-口途经传播,也有经输血传播的报道[1]。在发展中国家多因水源被HEV污染而发生戊型肝炎大规模流行,在发达国家主要是因摄入未煮熟的污染食物引起散发病例[2]。通常HEV感染后引起急性自限性肝炎,但是免疫功能低下的患者,合并HEV感染后可发生慢性化,甚至发展成肝硬化[3-5],孕妇感染HEV后病死率可高达20%[6]。最近还有报道,HEV感染后可引起一些严重的神[7-8] The novel hepatitis E virus (HEV) strain isolated from rabbits in 2009 caused extensive attention and investigation of its epidemiology, phylogenetics and pathogenesis. In this review, we summarized recent progresses in the research of the rabbit HEV strain about its epidemiology, phylogenetics, pathogenesis, and zoonotic transmission.
出处 《中国病毒病杂志》 CAS 2014年第1期1-6,共6页 Chinese Journal of Viral Diseases
基金 国家自然科学基金(81271827) 高等学校博士点专项科研基金(20120001110098)
关键词 戊型肝炎病毒 兔HEV 跨种系传播 致病性 Hepatitis E virus Rabbit HEV Zoonotic transmission Pathogenesis
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