摘要
目的 研究急性脑梗死后凝血与纤溶活性的变化规律。方法 检测 40例脑梗死患者发病时、病后 4～ 5天、病后 2周血浆纤维蛋白原 (Fg)、抗凝血酶Ⅲ (AT -Ⅲ )及D -二聚体 (D -dimer)的水平。 结果急性脑梗死后 2周内Fg持续升高 ;AT -Ⅲ在发病时及病后 4～ 5天明显降低 ;D -dimer在病时及病后 4～ 5天明显升高 ;AT -Ⅲ与D -dimer在发病后 2周末均恢复至正常。结论 较高水平的Fg促使脑梗死发生 ;急性脑梗死后有凝血及继发纤溶活性的增强 ,抗凝血活性降低 ,但病后 2周末多恢复正常。
Objective To study the changes of coagulation and fibrinolysis in patients' sera after acute cerebral infarction. Methods We investigated plasma levels of fibrinogen(Fg), antithrombin Ⅲ(AT-Ⅲ) and D-dimer in 40 patients with cerebral infarction within 2 days of onset, 4～5 days after onset and 2 weeks after onset respectively and compared these with 30 age-matched healthy controls. Results The plasma level of Fg increased continuously within 2 weeks after onset. The decreased plasma level of AT-Ⅲ and the increased plasma level of D dimer were found within both 2 days and 4～5 days after onset. The two markers changed to normal levels at the end of 2 weeks after onset. Conclusion High level of Fg was a risk factor of cerebral infarction. The activities of coagulation and fibrinolysis were high after acute cerebral infarction onset, but they gradually resume to normal at the end of 2 weeks after onset.
出处
《卒中与神经疾病》
2001年第1期20-22,共3页
Stroke and Nervous Diseases
