摘要
目的 观察动脉内接触性溶栓治疗急性脑梗死的临床疗效 ,评价其在神经功能障碍恢复和脑血管再通疗效。方法 选择急性脑梗死发病均在 6h以内 ,采用动脉内接触性溶栓进行治疗 ,溶栓药为尿激酶。结果 共有 9例患者入选 ,有 3例闭塞血管完全再通 ,5例部分再通 ,1例无再通 ,溶栓后患者神经功能缺损明显改善 ,治疗前后患者欧洲脑卒中评分有明显差异 (P <0 0 5) ,溶栓前后患者纤维蛋白原、凝血时间有明显差异 (P <0 0 5) ,1例出现消化道出血 ,1例伴有皮下出血 ,1例发生再灌注损伤。结论 动脉内接触性溶栓治疗急性脑梗死可以提高闭塞血管的再通率 ,明显促进神经功能障碍的恢复 ,改善血液高凝状态 ,副作用少 。
Objective: To observe the effect of acute cerebral infarction patients treated with local intra-arterial fibrinolysis (LIF). Methods: 9 cases of acute cerebral infarction patient were selected when their symptoms onset with in 6 hours. LIF was performed and urokinase was administered through a microcatheter placed into or proximal to a thrombus. Results: The rates of complete and partial recanalization of LIF were 3/9 and 5/9 respectively. There were significant differences in degrees according to the European stroke scale and in fibrinogen and clotting time between, before and after LIF respectively. Reperfusion injury of ischemic brain occurred in a patient. Conclusion: LIF therapy could be safe and effective in acute ischemic stroke. It could promote the rate of recanalization and supply a new and reliable mean to clinical treatment for acute cerebral infarction.
出处
《黑龙江医学》
2001年第1期5-6,共2页
Heilongjiang Medical Journal
关键词
动脉溶栓
急性脑梗死
再通
治疗
Local intra-arterial fibrinolysis
Acute cerebral infarction
Recanalization
