摘要
目的 :探讨幽门螺杆菌 (HP)及幽门螺杆菌细胞毒素相关蛋白 A(Cag A)与脑梗死发生的关系。方法 :用酶联免疫法 (EL ISA)和斑点金渗滤试验 (DIGFA)对 83例连续住院的脑梗死患者血清中幽门螺杆菌 Ig G抗体 (HP- Ig G)和幽门螺杆菌细胞毒素相关蛋白 AIg G抗体 (HP- Cag- Ig G)进行测定并设对照组比较。结果 :脑梗死组幽门螺杆菌感染率为 78.3% ,幽门螺杆菌细胞毒素相关蛋白 A阳性 HP感染率为 45 .8% ,而对照组分别为 5 6 .3%和 19.7% ,两组比较有显著差别。结论 :慢性 HP感染尤其是 Cag A阳性 HP菌株感染与脑梗死的发生有关 ,而且可能是脑梗死的独立危险因素。
Objective: To explore the relationship betwenn virulent Helicobacte pylori strains infection and cerebral infarction.Methods: We assessed the prevalence of infection by srtains bearing the cytotoxin-associated gene-A(Cag-A), a strong virulence factor, in 83 patients with cerebral infaction and in 71 age-and sex matched controls with similar social background.Results: Prevalence of Helicobacter pylori infection was significantly higher in pateints than in controls(78.3% versus 56.3%, P<0.05), with an odds ratio of 2.8(95% CI, 1.46 to 5.36)adjused of age, sex, main stroke factors. Patients with cerebral infarction also had a higher prevalence of Cag-A-positive strains(45.8% versus 19.7%, P<0.01), with an adjusted odds ratio of 3.43(95%CI 1.5 to 7.24).Conclusion: It was suggested that chronic Helicobacter pylori infection, especially Cag-A-positive strains infection is and independent risk factor for cerebral infarction.
出处
《脑与神经疾病杂志》
2001年第1期9-10,共2页
Journal of Brain and Nervous Diseases
