摘要
目的探讨幽门螺杆菌(Hp)细胞毒素相关蛋白A(CagA)与动脉粥样硬化性脑梗死的关系。方法测定100例动脉粥样硬化性脑梗死患者(脑梗死组)的CagAHpIgG抗体、中性粒细胞、C反应蛋白(CRP)、血糖、血脂、血纤维蛋白原,应用颈部彩色多普勒超声仪进行颈部血管检测,并与50名健康对照者进行比较。对Hp抗体阳性脑梗死患者给予抗Hp治疗。结果脑梗死组CagAHp抗体阳性率为62%,健康对照组为38%,两组相比差异有显著性(P<0.05)。Hp抗体阳性者颈动脉斑块和狭窄的发生率分别为100%和61%,健康对照组分别为55%和18%,差异有显著性(P<0.05)。Hp抗体阳性组较阴性组血CRP及纤维蛋白原明显升高(均P<0.05)。抗Hp治疗可促进脑梗死的恢复。结论CagA阳性Hp菌株感染与动脉粥样硬化性脑梗死有关,且可能是脑梗死的独立危险因素。
Objective To explore the relationship between helicobacter pylori cytotoxin-associated protein A （CagA） and atherosclerotic cerebral infarction. Methods Plasma levels of anti-CagA IgG, neutrophilic leukocyte, C-reactive protein, plasma glucose, lipid and fibrinogen were determined in 100 patients with atberosclerotic cerebral infarction and 50 normal controls. The presence of plaque instability was evaluated by color Doppler ultrasound. Hpantibody positive patients received anti-Hp therapy. Results The positive rate of CagA-Hp antibody was 62% in patient group and 38% in control group, there was a significant difference between the two groups （P 〈0.05 ）. There was a significant difference of the percentage of carotid atherosclerotic plaque and arteriostenosis between the patients with positive Hp antibody （100%, 61%, respectively） and the normal controls （55%, 18%, respectively）（ P 〈 0. 05 ）. Plasma levels of CRP and fibrinogen were significantly higher in Hp antibody positive patients than in Hp antibody negative patients （ P 〈 0. 05 ）. Anti-Hp therapy may promote the recovery of cerebral infarction. Conclusion CagA-positive strains infection may be an independent risk factor for atherosclerotic cerebral infarction.
出处
《临床神经病学杂志》
CAS
北大核心
2006年第4期272-274,共3页
Journal of Clinical Neurology
关键词
幽门螺杆菌
细胞毒素相关蛋白A
感染
脑梗死
helicobacter pylori, cytotoxin-associated protein A
infection
cerebral infarction
