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α1肾上腺素受体亚型对脊髓损伤大鼠膀胱排空的调节作用

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摘要 近年来,随着车祸等意外事故的增加,脊髓损伤( spinal cord injury ,SCI)发生率逐年升高,尤其对于年轻患者,提高损伤后的生活质量成为目前亟待解决的问题。 SCI后,排尿中枢受到损害或中断,从而导致尿潴留及排尿功能障碍[1],其中膀胱的并发症尤为困扰患者日常生活的难题。研究[2-5]发现,α1肾上腺素受体亚型a、b和d在尿道和膀胱均有分布,并对调节膀胱排空起着重要的作用。作者观察了α1肾上腺素受体亚型在大鼠SCI损伤模型膀胱组织中的表达变化,为用其治疗SCI后尿潴留及排尿困难提供理论支持。
出处 《郑州大学学报(医学版)》 CAS 北大核心 2014年第1期132-133,共2页 Journal of Zhengzhou University(Medical Sciences)
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