摘要
目的对幽门螺杆菌（Hp）感染与胃黏膜疾病及其病理改变的相互关系进行分析和探讨。方法选择700例胃黏膜疾病患者的胃黏膜活检切片作为研究对象，应用Giemsa染色和Warthin—Starry染色方法检测其中的Hp感染情况，并分析其与患者的胃黏膜疾病种类和标本病理变化之间的关系。结果700例标本中Hp阳性463例，Hp检出率为66．14％，慢性浅表性胃炎、慢性萎缩性胃炎、胃溃疡和胃癌患者的胃黏膜活体标本中的t4p检出率分别为46．86％、69．46％、83．62％和98．65％，四种疾病的Hp检出率总体差异和两两之间差异均有统计学意义（P〈0．05）；经过对所有标本的病理改变和Hp感染情况进行对比分析，结果显示发生萎缩性、活动性、伴肠化生、腺上皮不典型增生、淋巴滤泡形成等病理改变的标本中Hp的感染率显著升高（P〈0．05）。结论Hp感染与慢性胃炎、胃溃疡和胃癌等胃黏膜疾病及其病理变化具有相关关系，随着疾病的进展和组织病理结构变化的产生，Hp感染率呈现上升趋势，因此，及时对Hp进行根治对于防治胃黏膜疾病及其病理变化进展具有十分重要的意义。
Objective To analyze and investigate the relationship between Helicobacter pylori （Hp） infection and the gastric mucosa diseases and their pathological changes. Methods The gastric mucosa biopsy sections from 700 patients with gastric mucosa diseases were selected as the study objects. Hp infection of the biopsy sections was detected by Giemsa staining and Warthin-Starry staining method and the relationship between Hp infection and the gastric mueosa diseases and the pathological changes was analyzed. Results Among all 700 sections, there were 463 cases of Hp positive sections and the Hp positive detective rate was 66. 14%. The Hp detection rates of the gastric mucosa biopsy sections from patients with chronic superficial gastritis, chronic atrophic gastritis, gastric ulcer and gastric cancer were 46.86%, 69.46%, 83.62% and 98.65%. The overall difference of the Hp detection rates of the gastric mucosa biopsy sections from patients with each of the four diseases and the differences between every two diseases were significant （P 〈 0. 05 ） ; by analyzing the pathology changes and Hp infection of the gastric mucosa biopsy sections, the results showed the Hp infection rate of the gastric mucosa biopsy sections in which the pathological changes was atrophic changes, active changes, intestinal metaplasia, atypical hyperplasia of glandular epithelium, lymphoid follicles increased significantly （P 〈 0. 05）. Conclusions Hp infection is correla- ted with the gastric mucosa diseases such as chronic gastritis, gastric ulcer and gastric cancer and their pathological changes. As the diseases progresses and the pathological structure changes, Hp infection rate showes a rising trend. Therefore, timely treatment of Hp infection is very important for prevention and treatment of gastric mucosal diseases and the progress of their pathological changes.
出处
《中国实用医刊》
2014年第3期44-46,共3页
Chinese Journal of Practical Medicine
