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全基因组关联分析在畜禽中的研究进展 被引量：30

Progresses in Research of Genome-Wide Association Studies in Livestock and Poultry
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摘要 全基因组关联分析(genome-wide association studies,GWAS)是近几年发展起来的一种复杂性状研究的新方法。在过去几年中,国内外不少研究者对畜禽的重要经济性状、遗传缺陷性疾病、复杂疾病的抗性、品种的某些特征等性状开展了GWAS。这些研究不仅大大丰富了畜禽标记辅助选择中可利用的分子标记,而且为这些性状分子机理的探索研究提供了重要线索。本文对国内外畜禽GWAS中所用的群体、主要分析方法和研究结果进行综述,并对GWAS的研究应用做一展望,以期为进一步利用GWAS进行畜禽各种性状遗传基础的研究提供参考。 Genome-wide association study（GWAS） is a new research method for complex traits developed in recent years.In the last several years,many GWAS were performed focusing on economically important traits,genetic defect diseases,resistant or susceptible ability to complex diseases,breed characteristics of the main livestock and poultries.These studies not only enlarged molecular markers used in the marker-assisted selection,but provided important information for elaborate the genetic mechanism of these traits.In this study,the populations,main statistical methods and results of the GWAS in main livestock and poultry were reviewed.Furthermore,some prospect of GWAS in the future was made.This review will provide reference for further research on genetic background of the important traits of livestock and poultry by GWAS.
作者 王继英 王海霞 迟瑞宾 郭建凤 武英
机构地区 山东省农业科学院畜牧兽医研究所/山东省畜禽疫病防治与繁育重点实验室 山东省招远市畜牧兽医总站
出处 《中国农业科学》 CAS CSCD 北大核心 2013年第4期819-829,共11页 Scientia Agricultura Sinica
基金 优质肉猪新品种(配套系)选育研究(2010LZ013-01) 转基因生物新品种培育重大专项(2011ZX08006-005) 国家生猪产业技术体系(CARS-36) 山东省农业产业技术体系生猪创新团队建设项目
关键词 全基因组关联分析(GWAS) 畜禽 遗传变异 单核苷酸多态性(SNP) genome-wide association studies（GWAS） livestock and poultry genetic variation single nucleotide polymorphism（SNP）
分类号 S852 [农业科学—基础兽医学]
  • 相关文献

参考文献75

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二级参考文献32

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共引文献53

同被引文献287

引证文献30

二级引证文献99

中国农业科学
2013年 第4期

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