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骨质疏松症的全基因组连锁及关联研究进展

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摘要 骨质疏松症是由多个微效基因及多种环境因素共同作用所致的一种全身性骨骼疾病，以骨量下降和骨折风险增加为主要特征。双生子及家系研究估计65％～80％的峰值骨密度（BMD）的变异是遗传因素决定的。研究还发现很多骨折风险的决定因素也受遗传效应的影响，包括骨量、
作者 赵晶 夏维波
机构地区 中国医学科学院北京协和医学院北京协和医院内分泌科卫生部内分泌重点实验室
出处 《中华医学杂志》 CAS CSCD 北大核心 2009年第42期3012-3015,共4页 National Medical Journal of China
关键词 骨质疏松症 全基因组 全身性骨骼疾病 连锁 骨折风险 峰值骨密度 环境因素 微效基因
分类号 R686 [医药卫生—骨科学]
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共引文献51

中华医学杂志
2009年 第42期

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