摘要
目的 :探讨病毒感染在小儿肾脏病发病中的致病作用及临床意义。方法 :应用聚合酶链反应 (PCR)检测了 2 2 4例小儿肾病患者血清及肾活检组织中乙型肝炎病毒 (HBV)、丙型肝炎病毒 (HCV)、EB病毒 (EBV)和巨细胞病毒 (CMV)基因表达情况。结果 :小儿肾病患者血清和肾组织中HVBDNA检出阳性率分别为 2 1 4%和 19 6 % ;HCVRNA阳性率为 4.0 %和 3.1% ;EBVDNA阳性率为 1.8%和 0 .5 % ;CMVDNA阳性率为 0 .9%和 0 .5 %。结论 :HBV感染在小儿肾脏疾病发病因素上起着重要的作用 ,HCV感染与小儿肾病的关系尚不明确 。
Objective:In order to know the pathogenetic mechanism of virus infection in nephropathy of children.Methods:HBV DNA,HCV RNA,EBV DNA and CMV DNA were detected in the sera and renal tissue of 224 patients using a polymerase chain reaction (PCR).Results:The positive rate of HBV DNA in the sera and renal tissue was 21.4% and 19.6% respectively;HCV RNA was 4.0% and 3.1%;EBV DNA was 1.8% and 0.5%;CMV DNA was 0.9% and 0.5%.Conclusion:Infection of HBV play a significantly action on the etiology of nephropathy in children.The corelation between infection of HCV and nephropathy is not defined nowadays,but pathogenetic mechanism of nephropathy in children may not related to the infection of EBV and CMV.
出处
《中国中西医结合肾病杂志》
2001年第2期88-90,共3页
Chinese Journal of Integrated Traditional and Western Nephrology
基金
"九五"全军青年基金资助项目 (No .A970 17)
