摘要
目的建立氯霉素水杨酸搽剂的微生物限度检查方法。方法参照《中国药典》2010版,采用5种阳性对照菌回收率试验测定其是否含抑菌成分。结果该品种对大肠埃希菌、枯草芽孢杆菌、金黄色葡萄球菌、白色念珠菌和黑曲霉均没有抑菌活性,细菌、霉菌和酵母菌数及控制菌的检查采用常规法进行。结论用该方法进行微生物限度检查可以客观地反映药物中微生物的污染状况,可用于该制剂微生物控制。
Method According to China Pharmcopoeia edition 2010,the antimicrobial effect of Chloramphenicol salicylic acid liniment was determined by recovery rate with 5 control trains.Result Antibacterial effect was not found against escherichia coli,bacillus subtilis,staphylococcus aureus,Candida albicans and Aspergillus niger.Conventional method was used for counting bacteria. Gonc lusion The method is sample and it can be used for qualitity control of Chloramphenicol salicylic acid liniment.
出处
《首都医药》
2014年第2期55-56,共2页
Capital Medicine
关键词
氯霉素水杨酸搽剂
微生物限度检查法
常规法
Chloramphenicol Salicylic AcidLiniment
Microbial Limit Test
ConventionalMethod
