摘要
目的:观察蜂针对佐剂性大鼠类风湿性关节炎(RA)白细胞介素-15(IL-15)的影响。方法:将120只大鼠随机分为蜂针治疗组、激素治疗组、病理模型组、正常对照组,每组各30只。正常对照组不造模,其余3组采用Freund氏完全佐剂制造大鼠关节炎模型。蜂针治疗组:取肾俞、足三里、命门、大椎穴,用镊子轻轻捏住蜜蜂的腰部,将其尾部对准穴位,让其自然蛰入穴位并留针10 min。均治疗21天,用ELISA法检测外周血IL-15水平。结果:与正常对照组比较,病理模型组、激素治疗组、蜂针治疗组IL-15水平均升高,差异均有显著性意义(P<0.05);与病理模型组比较,激素治疗组、蜂针治疗组IL-15水平明显下降,差异均有显著性意义(P<0.05);与激素治疗组比较,蜂针治疗组IL-15水平略高,差异有显著性意义(P<0.05)。结论:蜂针治疗RA可以有效降低IL-15水平,从而有效缓解RA病情。
Objective： To observe the effect of bee venom therapy on interleukin-15（IL-15）in rats with adjuvant-induced rheumatoid arthritis. Methods. One hundred and twenty rats were equally randomized into bee venom group, hormone group, model group and normal group. Except the normal group, rats in the other three groups were given Freund＇s complete adjuvant to induce rheumatoid arthritis. Bee venom group was stung by the bees for 10 min on acupoints of Shenshu, Zusanli, Mingmen and Dazhui. After treatment, enzyme-linked immunosorbent assay（ELISA） was used for the detection of peripheral blood IL-15 level. Results： In comparison with normal group, IL-15 was increased in model group, bee venom group and hormone group（P 〈0.05）. After treatment, IL-15 was decreased in bee venom group and hormone group（P〈0.05 compared with the model group）, and bee venom group had higher IL-15 than hormone group （P 〈0.05）. Conclusion： Bee venom therapy is effective for the treatment of adjuvant-induced rheumatoid arthritis bv decreasinq IL-15 in rats.
出处
《新中医》
CAS
2014年第2期197-199,共3页
New Chinese Medicine
基金
广东省中医药局课题(编号:2010226)
