摘要
目的 了解育龄妇女、新生儿麻疹抗体水平及其关系 ,婴儿胎传抗体衰减情况 ,不同月龄婴儿对麻疹疫苗的免疫应答情况 ,探讨减少小月龄麻疹病例的对策。方法 采用ELISA方法测定血清中麻疹IgG抗体水平。结果 5 8对育龄妇女及其婴儿中有 5 1对麻疹抗体相同 ,7对不同 ,但只相差 1个滴度 ,且两者抗体均处于低水平。通过对胎传抗体追踪观察发现 ,新生儿抗体水平不高 ,3月龄时降低 5 0 %,6月龄和 8月龄降到 15 %左右 ,抗体水平很低 ,几乎无保护作用 ,且 6月龄和 8月龄婴儿接种疫苗后免疫成功率间无差别。结论 说明母婴麻疹抗体间有密切关系 ,由于目前育龄妇女麻疹抗体水平低 ,因此 ,可通过对育龄妇女接种麻疹疫苗来提高婴儿抗体水平 ,同时建议在某些地区将麻疹初免时间从 8月龄提前到
Objective To understand: a) measles antibody levels in puerpera and their newborns, and the relation between them, b) maternal transferred measles antibody level of different age group infants, c) immunization rates of success in 6 and 8 month old infants, d) to study measles control countermeasures on infants. Method To test measles IgG antibody levels of infant's blood using ELISA method. Results Antibody levels of measles in 58 pairs of mother and their newborns, 51 pairs were the same, while 7 pairs were different. Measles antibody levels in newborns was not high and reduced to 50% in 3 months, 20% in 6 months, and 15% in 8 months. The antibody levels in 6 and 8 month olds were low, nearly no protection to children. It was found that rates of immunization success and the antibody distribution were not statistically different between 6 and 8 months olds after measles vaccination. Conclusion It was found that the measles antibody level in most matured women was low. Since mother's measles antibody level has close relation to their newborns, it seems that the newborn's antibody level can be improved by vaccination to matured women. In order to reduce morbidity of infant measles, the age of first vaccination of measles vaccine should be changed from 8 months old to 6 months old in some regions.
出处
《中华流行病学杂志》
CAS
CSCD
北大核心
2001年第1期49-50,共2页
Chinese Journal of Epidemiology
