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抗菌肽LL-37在慢性鼻窦炎中作用的研究现状

A review:the role of antimicrobial peptide LL-37 in chronic sinusitis
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摘要 近年来研究发现,先天性免疫在呼吸道炎性疾病如哮喘及慢性鼻窦炎（chronic rhinosinusitis,CRS）的发病机制中占有举足轻重的作用,而先天性免疫对于黏膜表面的感染的第一道防线作用,是通过多种免疫效应分子,如toll样受体、表面蛋白、以及抗菌肽等早期识别微生物抗原、进行初始的抗菌活动以及激活特异性免疫实现的〔1-5〕。LL-37是迄今在人体中发现的抗菌肽cathelicidin家族中的唯一成员,在宿主防御反应中起着重要作用。本文就LL-37研究现状及其在慢性鼻及鼻窦炎中的作用做一综述。 Summary The purpose of this review is to explain the function of iris. LL-37 is the only human cathelicidin identified so far. LL-37 is an of which in chronic sinusitis is attracting more and more s attention. LL-37 in the pathogenesis integral part of the innate of chronic sinus- immune, the role
作者 宗雨 李吉平
机构地区 上海交通大学医学院附属仁济医院耳鼻咽喉-头颈外科 上海交通大学医学院耳鼻咽喉科研究所
出处 《临床耳鼻咽喉头颈外科杂志》 CAS 北大核心 2014年第2期141-142,共2页 Journal of Clinical Otorhinolaryngology Head And Neck Surgery
关键词 抗菌肽LL-37 鼻窦炎 发病机制 先天性免疫 LL-3 7 antimicrobial peotide sinusitis pathogenesis innate immune
分类号 R765.4 [医药卫生—耳鼻咽喉科]
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参考文献18

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二级参考文献34

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临床耳鼻咽喉头颈外科杂志
2014年 第2期

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