摘要
膜活性多肽(MAPs)是一类具有较好抗菌活性的抗菌肽。作为先天宿主防御分子,广泛的分布于细菌、植物、无脊椎动物、脊椎动物中。膜活性多肽具有抗菌肽的结构特征,肽链通常较短,带正电荷,具有两亲性的α-螺旋或β-折叠结构,通过破坏膜的通透性杀死细菌、真菌和部分肿瘤细胞。膜活性多肽在细胞膜或细胞内部存在特定的分子靶点,并因其独特的作用机制而成为一种新型的肽类抗生素。本文主要对膜活性多肽的抗菌活性及其作用机制的研究现状和发展情况做一综述。
Membrane-active peptides （MAPs） are one kind of antimicrobial compounds with good antimicrobial activity. As the innate host defense molecules, membrane-active peptides have been distributed widely in bacteria, plants, invertebrates, vertebrates. With structural features of antimicrobial peptides, membrane-active peptides are usually short, positively charged, amphiphilic α-helix or β-sheet structure. They kill bacteria, fungi and some tumor cells by destroying the permeability of membrane. Membrane-active peptides have specific molecular targets in the cell membrane or cell interior, and they have become a new type ofpeptide antibiotics contribute to their unique action mechanism. A brief overview of antibacterial activity, action mechanism and the development of membrane-active peptides are reviewed in this paper.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2012年第3期161-167,共7页
Chinese Journal of Antibiotics
基金
国家自然科学基金(No.30970352)
关键词
膜活性多肽
抗菌活性
作用机制
Membrane-active peptides
Antibacterial activity
Action mechanism
