摘要
目的观察大剂量维生素D治疗高血压并尿蛋白患者的临床效果,为临床治疗高血压并尿蛋白提供参考依据。方法对确诊为高血压并尿蛋白的患者随机分成对照组与治疗组,对照组使用卡托普利片治疗,治疗组在对照组的基础上加用大剂量维生素D330万U肌注1次,观察高血压并尿蛋白患者1个月时的血压、尿蛋白、肾素、血管紧张素水平变化的情况。结果治疗1个月时,治疗组较对照组收缩压与舒张压水平、肾素与血管紧张素水平明显降低(p<0.05)、尿蛋白转阴率明显增加(p<0.05)。结论大剂量维生素D治疗高血压并尿蛋白患者疗效较好,值得推广。
Objective To observe the clinical effect of high dose vitamin D in the treatment of patients with hypertension and proteinuria, provide reference for the treatment of hypertension and proteinuria. Methods Patients with hypertension and proteinuria were randomly divided into control group and treatment group, the control group u- sing captopril, the treatment group using large doses of vitamin D330 million U intramuscular injection one times based on the control group. Observed the blood pressure, changes in urine protein, renin, angiotensin level one month later. Results After one month later, compared with the control group, the systolic and diastolic blood pres- sure levels, renin and angiotensin levels decreased significantly （p 〈 0. 05 ）, urine protein negative rate was significantly increased （p 〈 0. 05）. Conclusion Large dose of vitamin D in treatment of patients with hypertension and proteinuria has good effect and is worthy promoting.
出处
《现代医院》
2014年第1期43-45,共3页
Modern Hospitals
基金
湛江市科技攻关计划项目(编号:2013B01279)
关键词
维生素D
高血压
尿蛋白
临床
Vitamin D, hypertension, proteinuria, Curative effect
