摘要
目的 :探讨基质金属蛋白酶 - 2 (MMP - 2 ,72kD、6 2kD)的活性与乳腺癌侵润、转移的关系。方法 :利用酶谱和计算机软件检测并分析了 35例乳腺癌组织中MMP - 2活性。结果 :乳腺癌MMP(72kD)的水平低于乳腺癌 ,P <0 0 5 ;MMP (6 2kD +72kD)乳腺纤维腺瘤与乳腺癌比较时 ,P >0 0 5。同时发现MMP(6 2kD)乳腺癌组 (13 83± 4 5 3)明显高于乳腺纤维腺瘤 (6 89± 2 94) ,P <0 0 5 ;MMP(6 2kD/6 2kD +72kD) :乳腺癌组 (0 48)明显高于乳腺纤维瘤 (0 2 4) ,P <0 0 1;转移组 (0 6 1)明显高于无转移组 (0 42 ) ,P <0 0 1;浸润组 (0 48)明显高于非浸润组 (0 36 ) ,P <0 0 1。结论 :MMP - 2的活性水平与乳腺癌的侵袭、转移有关。
AIM: To investigate relationship between activity of matrix metalloproteinases-2 ( MMP-2, 72 kD) and invasion, metastasis of breast cancer. METHODS: Useing zymography and computer software assisted analysis, the activitive levels of MMP-2 (72 kD) in tissues from breast cancer were measeured. RESULTS: Mean activitive levels of MMP-2 72 kD (13.93±3.60) in breast cancer were lower than those in benign disease (21.43±8.31), P<0.05. There was no difference (P>0.05) in MMP-2 62 kD+72 kD of benign and malignant disease, but MMP-2 62 kD (13.83±4.53) and MMP-2 62 kD/62 kD+72 kD(0.48) respectively were significantly higher in malignant disease (P<0.01). It was also found that MMP-2 62 kD/62 kD+72 kD were apparently higher in invasive carcinomas (0.48) and lymph node metastases (0.61), P<0.01, respectively. CONCLUSION: These results demonstrated that a clear relationship between MMP-2 activity and the invasion and metastasis of breast carcinoma.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2000年第12期1295-1297,共3页
Chinese Journal of Pathophysiology
基金
河南省自然科学基金资助! (No .9740 2 32 0 0 )
