摘要
目的 :探讨明胶酶在食管癌中的表达及其意义。方法 :以明胶酶谱 (gelzymography)法对 35例食管癌 (其中 2 7例鳞癌、8例腺癌 )及 8例正常食管粘膜组织中明胶酶表达水平进行检测。结果 :明胶酶 (MMP 2、pro MMP 2和MMP 9)在癌组织和正常粘膜中表达差异有显著性 (P <0 0 5 ) ;有淋巴结转移组 (3～ 4期 )显著高于无淋巴结转移组(0～ 2期 ) (P <0 0 5 )。结论 :明胶酶与食管癌的发生发展 ,特别与肿瘤的侵袭转移关系密切 ,并且有望成为判断食管癌临床预后的新指标 ;明胶酶谱法是检测IV型胶原酶的有效方法。
Aim: To explore the expression of gelatinases in esophageal cancer and its significance Methods: Gel zymography was used to examine the contents of gelatinases in 35 tissue samples of esophageal cancer, including 27 samples of squamocellular cancer and 8 samples of adenocarcinoma Eight samples of normal mucosas were used as control Results: There existed significant difference in contents of gelatinase between cancer tissues and normal controls ( P <0 05) Expression of gelatinases in the group with metastatic lymph nodes was higher than that without ( P <0 05) Conclusions: Gelatinases are correlated to occurrence and evolution of esophageal cancer,especially to those with lymph node metastasis Gel zymography is an effective method to examine the contents of gelatinases
出处
《郑州大学学报（医学版）》
CAS
北大核心
2002年第2期197-199,共3页
Journal of Zhengzhou University(Medical Sciences)
