摘要
目的 探讨转化生长因子β1 (TGF-β1 )和口腔鳞癌侵袭及转移的关系。方法 应用酶联免疫吸附法测定 40例口腔鳞癌根治性手术前后患者血清 TGF- β1 浓度 ;免疫组化法分析癌灶组织的 TGF- β1 蛋白表达水平。结果 伴有颈淋巴结转移组的血清 TGF- β1 浓度和 TGF- β1 蛋白表达水平高于无淋巴结转移组 (P<0 .0 5～ 0 .0 1) ,切除癌灶后上述各组的血清 TGF- β1 浓度均明显下降 (P<0 .0 5 )。结论 TGF- β1
WT5”BZ] Objective To detect the role of transforming growth factor β 1(TGF β 1) on the invasiveness and metastasis of human oral squamous cell carcinoma.Methods Using ELISA, fasting concentration of serum TGF β 1 was determined in 40 patients with oral squamous cell carcinoma before and after radical operation, The expression of TGF β 1 protein in the tumor was analyzed by immunohistochemistry. Results The serum TGF β 1 concentration and the TGF β 1 protein expression level in the groups with metastatic neck lymph nodes were significantly higher than those in the groups without metastatic lymph nodes ( P <0.05~0.01); After the removal of the tumors, TGF β 1 concentration was dramatically decreased ( P <0.05) in all groups. Conclusion Serum TGF β 1 may be a factor associated with the invasive and metastatic poteneial of oral squamous cell carcinoma. [WT5”HZ]
出处
《临床口腔医学杂志》
2000年第4期200-201,共2页
Journal of Clinical Stomatology
