摘要
基于复杂网络研究蛋白质界面网络中的模体和模块,发现蛋白质界面网络与蛋白质肽链网络的拓扑性质有差异.蛋白质界面网络中的模体类型和数量受截断距离R影响较大,R值不同,网络中的模体类型和数量都有较大差别.蛋白质界面网络中存在模块结构,分析R为0.5,0.7,1.2,2.4nm时网络中存在的3-派系-模块,发现当R为0.7nm时的蛋白质界面网络模块划分比较符合实际.最后,分析蛋白质界面网络中的模块与其拓扑性质的关系,发现界面网络中的节点数与3-派系-模块数呈线性关系.
The motifs and modules in protein interface networks are researched in this paper, it is found that there are differences between the topology properties of protein interface networks and protein peptide networks. The type and number of motifs in protein interface networks are greatly affected by cutoff distance R, if R is different, the type and number of motifs in networks are different. The modules are existed in protein interface networks, 3-clique-modules are analyzed when R is 0. 5, 0. 7, 1.2, 2.4 nm, it is found that the module partitions are consistent with the fact when R is 0. 7 nm. At last, the relationship between modules and the topological properties of protein interface networks is researched, result shows that there is a linear relationship between the number of nodes and the number of 3-clique-modules in protein interface networks.
出处
《华侨大学学报（自然科学版）》
CAS
北大核心
2014年第1期61-66,共6页
Journal of Huaqiao University(Natural Science)
基金
国家科技支撑计划项目(2008BAH37B05-040)
国家科技人员服务企业行动项目(2009GJC40029)
关键词
蛋白质
肽链网络
界面网络
模体
模块
拓扑性质
protein
peptide network
interface network
motif
module
topological property
