摘要
目的:通过文献检索,分析常用有毒中药不良反应发生的靶器官和发生频率,为临床不良反应有效监测提供文献数据支持。方法:收集和分析有毒中药不良反应报道文献;按中药类别对药典记载的有毒中药易发生不良反应的靶器官进行整理和分析。结果:根据文献报道分析,有毒中药不良反应易发生靶器官包括胃肠道、心脏、肝脏、肾脏、脑、口舌、眼、肺、脾、睾丸、卵巢,其发生频率为:胃肠道30%、心脏21%、肝脏12%、肾脏11%、脑7%、口舌7%、眼5%、肺4%、脾2%、睾丸0.7%、卵巢0.3%。结论:有毒中药发生不良反应的原因是多方面的,是多种因素综合作用的结果。明晰不良反应发生的原因、特点以及易发生靶器官,能有效地规避不良反应的发生,为安全使用有毒中药提供重要保障。
Objective： To analyze the target organ and occurrencing frequency of the adverse reactions of commonly used toxic tradi- tional Chinese medicine by retrieving literature, and provide documentary data for monitoring effectively the clinical adverse reactions. Methods： The reports and literatures of the adverse reactions of toxic traditional Chinese medicine were searched and analyzed. The tar- get organ of toxic traditional Chinese medicine, which Chinese Pharmacopoeia records, were analyzed and collected according to category of the traditional Chinese medicine. Results： The target organ of the adverse reactions of toxic traditional Chinese medicine include gas- trointestional tract, heart, liver, kidney, brain, eye, lungs, spleen, testis, ovary etc, the occurrencing frequency of which, is 30%, 21% ,12% ,11% ,7% ,7% ,5% ,4% ,2% ,0. 7% ,0. 3%. Conclusion： It has various reasons that toxic traditional Chinese medicine has adverse reactions, and the adverse reactions is the result of multi-factor interacting. The adverse reactions could be avoided efficaciously, and the toxic traditional Chinese medicine＇ s safe usage could be insured by determining the reasons, characteristics and incident target organs of adverse reactions.
出处
《中国药物评价》
2013年第6期353-356,共4页
Chinese Journal of Drug Evaluation
基金
国家重点基础研究发展计划(973)中医基础理论专项资助项目课题2(2009CB522802)
山东省中医药现代化专项平台建设类课题:基于中医药理论和国际化的中药肝毒性评价技术平台建立(2008GG2NS02021)
关键词
有毒中药
不良反应
靶器官
文献研究
Toxic Chinese medicine
Adverse reaction
Target organ
Literature research
