摘要
目的研究茜草科植物红大戟Knoxia valerianoides根的化学成分。方法应用硅胶柱色谱、Sephadex LH-20柱色谱和半制备型反相高效液相色谱等方法进行分离和纯化,通过MS、NMR等波谱数据鉴定化合物的结构。结果从红大戟干燥根的95%乙醇提取物中分离得到1个降碳三萜,结构鉴定为3-氧代-2,19-二羟基-24-降乌苏-1,4,12-三烯-28-酸(1)。结论化合物1为新化合物,命名为红大戟酸A。
Objective To investigate the chemical constituents from the root tubers of Knoxia valerianoides. Methods The constituents were isolated and purified by using a combination of chromatographic techniques including column chromatography over silica gel, Sephadex LH-20, and reverse-phase HPLC. The structures were identified by spectroscopic analyses including MS, and NMR. Results A new nor-triterpenoid was isolated from the ethanol extract in the dried root rubers ofK. valerianoides, and its structure was identified as 3-oxo-2, 19-dihydroxy-24-nor-urs-1, 4, 12-trien-28-oic acid （1）. Conclusion Compound 1 is a new compound named knoxivalic acid A.
出处
《中草药》
CAS
CSCD
北大核心
2014年第1期28-30,共3页
Chinese Traditional and Herbal Drugs
基金
国家自然科学基金资助项目(31170321)
山东省自然科学基金资助项目(ZR2011HL067)
滨州医学院校启动基金资助项目(BY2010KYQD12)
