摘要
纳米粒子最新的研究集中在纳米粒子和体液、细胞微环境、胞内成分或细胞分泌蛋白如细胞因子、生长因子和酶等生物分子的互作方面,进而研究癌症治疗中工程纳米粒子所靶标的不同信号转导路径.纳米粒子诱导的毒理机制是近几年热议的话题,氧化压力不是纳米粒子引起细胞毒性的惟一生物学效应.从细胞机制角度综述了纳米毒理学的最新研究进展,包括纳米粒子与细胞膜和受体间的互作、纳米粒子与细胞信号通路间的互作、纳米粒子对细胞凋亡的诱导和对细胞周期的影响.
New progress in the area of nanoparticle research are the studies on interactions between nanoparticles （NPs） and biological molecules in body fluid,cellular microenvironment,intracellular components or secreted cellular proteins such as cytokines,growth factors and enzymes and the use of engineered NPs to target various signal transduction pathways in cancer therapy.NPs-induced toxicological mechanism has become one of the most studied topics.Oxidative stress result is not sufficient to explain all the biological effects.This article reviews the latest research progress in nanotoxicology from the perspective of cellular mechanisms,including the interactions between NPs and the cell membrane receptor,cell oxidative stress result,cell apoptosis induction and the effects of NPs on cell cycle.
出处
《国际生物医学工程杂志》
CAS
2013年第6期381-384,共4页
International Journal of Biomedical Engineering
