摘要
目的总结原发于中枢神经系统中的Rosai—Dorfman病的临床特点，探讨其诊治方法及预后。方法结合文献回顾分析2010～2012年收治的3例原发于中枢神经系统中的Rosai—Dorfman病例临床特点、影像、病理学特点、治疗方案及预后。结果1例患者颅内多发，最大病灶予以全切，其余分阶段予以类固醇及放射治疗，回访1年示手术病灶无复发，余病灶无明显改变；1例颅底多发且呈匍匐样生长，最大病灶部分切除，余病灶随访观察1年略增大；1例颅内单发，完整切除后回访2年无复发。结论原发于中枢神经系统中的Rosai—Dorfman病罕见，影像与脑膜瘤相似；病理特点是淋巴细胞和浆细胞伸入到体积较大胞浆丰富的组织细胞中；手术治疗为首选方案，类固醇及放射治疗疗效不确定。
Objective To summarize the clinical characteristics of Rosai -Dorfman disease primarily involved in central nervous system and to explore the diagnosis and treatn^nt. Methods Retrospectively evaluated the clinical, imaging and pathological characteristics as well as treatment and pint.sis of three eases of Rosai - Doffman disease primarily involved in central nervous system and reviewed the literature simultaneously. Results In case one, the largest lesion of multiple inaaeranial lesions was totally reseeted, followed by steroid administration and radiotherapy for rest lesions, with no regrowth at 1 year follow up. tin ease 2, multiple intracranial lesious lived in sheelgrowth, and the largest lesion was subtotally resected and the ~sidual showed small growthat 1 -year following up. In case 3, the isolate lesion received total resection and didn＇t recur during the 2- years foUowutx Conclusions Rosai- Dorfman disease primarily involved in central nervous system is rare, with similar imaging characteristics to those of meningiomas, and the pathological features indicated as lymphocytes and plasma cells reaching tissue cells with large volume and abundant cytoplasm Operation is the frontlinetreatment, while the effects by steroid administration and radiotherapy are not reliable.
出处
《中华神经外科杂志》
CSCD
北大核心
2014年第1期59-62,共4页
Chinese Journal of Neurosurgery
基金
南京市卫生局青年启动项目基金（QYK11126）
南京市第三层次青年卫生人才计划项目资助
