摘要
目的研究复方聚桂醇化学消融肿瘤作用及局部镇痛效果，探索一种超声引导下高效无痛的肿瘤局部消融方法。方法新西兰大白兔右后肢肌层接种VX2瘤细胞建立肿瘤模型，选取瘤径约2．0～2．5cm的18只荷瘤兔随机分为生理盐水对照组、无水乙醇组、复方聚桂醇组，超声引导下瘤内注射相应药物，治疗结束后行肿瘤超声造影，剥离肿瘤计算生长抑制率，并行肿瘤组织病理检查。采用甲醛试验观察复方聚桂醇对小鼠局部镇痛作用。结果超声引导复方聚桂醇瘤内注射具有明显的抗兔VX2肿瘤作用，抑瘤率高达63．3％，高于无水乙醇组的39．4％，超声造影见肿瘤基本无增强，病理检查见肿瘤广泛坏死。生理盐水组、利多卡因组、复方聚桂醇组甲醛试验平均积分分别为62．25±9．79、21．00±9．13、9．87±3．10。结论超声引导复方聚桂醇瘤内注射具有更彻底的化学消融肿瘤作用，并具有明显镇痛作用，有望为超声引导化学消融肿瘤提供一种新的药物选择。
Objective To investigate the tumor chemical ablation and analgesic effects of compound lauromacrogol,and to explore a new method for ultrasound-guided tumor ablation. Methods 18 VX2 tumor- bearing rabbits were randomly divided into saline group, ethanol group and compound lauromacrogol group, and the medicine was intratumoral injected guided by ultrasonography. After 4 times treatment, tumor contrast-enhanced ultrasonography, tumor growth inhibition rate and tumor tissue pathology were performed to evaluate the antitumor effects. The analgesic effect was evaluated using the pain model induced by formaldehyde test. Results Ultrasound-guided intratumoral injection of compound lauromacrogol showed significant antitumor effects with a tumor growth inhibition rate of 63.3 ~, which was higher than that of ethanol group. No apparent enhancement was found under contrast-enhanced ultrasonography, and pathology results confirmed wide necrosis. In saline, ethanol and compound lauromacrogol groups, the average accumulated points were 62.25 ± 9.79,21.00 ± 9.13 and 9.87 ± 3.10,respectively by formaldehyde test. Conclusions Ultrasound-guided chemical ablation using compound lauromacrogol showed complete antitumor and strong analgesic effects,which would be a new method for tumor ablation.
出处
《中华超声影像学杂志》
CSCD
北大核心
2014年第1期62-65,共4页
Chinese Journal of Ultrasonography
关键词
超声检查
介入性
肿瘤
实验性
聚桂醇
乙醇
Ultrasonography
interventional
Neoplasms, experimental~ Lauromacrogol ~ Ethanol
