摘要
目的:探讨黄芪对慢性肾功能衰竭血液透析(HD)患者肿瘤坏死因子-α(TNF-α)和脂蛋白(a)[Lp(a)]的影响。方法:用RIA法和ELISA法分别测定21例HD患者在HD前、后及黄芪治疗后血清TNF-α和Lp(a)水平。结果:HD患者血清TNF-α、Lp(a)、载脂蛋白B(Apo-B)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDLC)、极低密度脂蛋白胆固醇(VLDL-C)均升高(P<0.01),而Apo-A_1、Apo-A_1/Apo-B、高密度脂蛋白胆固醇(HDL-C)均降低(P<0.01)。HD前、后TNF-α和血脂各值均无明显变化(P>0.05)。黄芪治疗后TNF-α、Lp(a)、TC、TG、LDL-C、VLDL-C均降低(P<0.05或P<0.01),而Apo-A_1、Apo-A_1/Apo-B、HDL-C均升高(P<0.05或P<0.01)。结论:(1)维持性HD患者有TNF-α升高和高脂血症。(2)HD不能纠正TNF-α异常和脂质代谢紊乱。(3)黄芪对维持性HD患者的TNF-α异常和脂质代谢紊乱有调节作用。
To explore the effect of astragali on tumor necrosis factor- (alpha) (TNF-α) and lipoprotein (a) [Lp(a)] in hemodialyzed (HD) patients. Methods: Double antibody sandwich ELISA and RIA were used to determine serum Lp(a) and TNF-α levels from 21 HD patients (pre-and post-hemodialysis, after astragali treatment). Results: Serum TNF-α, Lp(a), apolipoprotein B (apo B),total cholesterol (TC) , triglyceride (TG),low density lipoprotein-cholesterol (LDL-c) and very low density lipoprotein-cholesterol (VLDL-c) concentrations in HD patients were significantly higher than those in control (P<0.01) . Serum apo Al,apo Al/apo B and high density lipoprotein-cholesterol (HDL-c) levels were significantly lower than those of normal control ( P <0.01) . There were no changes of TNF-α and lipid levels in 21 HD patients between pre-and post-hemodialysis (P>0.05). After astragali treatment, the levels of TNF-α, Lp(a), TC, TG, LDL-c and VLDL-C were decreased (P<0.05 or P<0.01) ,and the levels of apo Al,apo Al/apo B,HDL-c were increased (P<0.05 or P< 0.01). Conclusion:(1) The continuous HD patients were characterized by the increased TNF-α and hyperlipoproteinemia. (2)The disorder of TNF-α and lipid metabolism could not be corrected with HD. (3)The astragali treatment could improve the disorder of TNF-α and lipid metabolism in HD patients.
出处
《天津医药》
CAS
北大核心
2001年第1期9-11,共3页
Tianjin Medical Journal
