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分泌型磷脂酶A_2在肺损伤中的作用

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摘要 肺损伤（injury of lung）按照时效性可分为急性肺损伤和慢性肺损伤.急性肺损伤（acute lung injury,ALI）是各种复杂因素导致的肺泡上皮细胞及毛细血管内皮细胞损伤,造成弥漫性肺间质及肺泡水肿,严重阶段（氧合指数＜ 200）也称为急性呼吸窘迫综合征（acute respiratory distress syndrome,ARDS）.慢性肺损伤为慢性支气管炎、肺间质纤维化形成或肺癌等慢性损伤.分泌型磷脂酶A2（sPLA2）是花生四烯酸、溶血磷脂等炎性介质的限速酶,它促进一系列炎性介质和细胞因子释放和激活,参与多种急、慢性炎症病变.
作者 张丽娟 余舰
机构地区 合肥医学院附属医院司法鉴定中心
出处 《合肥医学院学报》 2013年第6期598-601,共4页 Journal of Zunyi Medical University
基金 贵州省科技厅基金资助项目(NO:黔科合J字[2012]2358)
关键词 分泌型磷脂酶A2 肺损伤 急性呼吸窘迫综合征 哮喘 肺癌 胎粪吸入综合症 肺间质纤维化
分类号 R563.9 [医药卫生—呼吸系统]
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参考文献35

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二级参考文献10

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合肥医学院学报
2013年 第6期

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